200 Section - Quality of Life and Bone Mineral Density in Breast Cancer Women Undergoing Adjuvant Hormonal Therapy : An Italian Correlational Study

Objectives : Cancer Treatment Induced Bone Loss is frequent in Breast Cancer (BC) and Bone Mineral Density (BMD) evaluation is recommended. Our study aims to explore the correlation between Health Related Quality of Life (HRQoL) and BMD among BC women.
 

Design: This is a correlational single-center study including 52 BC women undergoing adjuvant hormonal treatment. Given their free and informed consent, women completed 2 HRQoL questionnaires: the ECOS-16, for osteoporosis, and the 12-Item Short Form Health Survey (SF-12). We recorded age, MOC-DEXA scores, and ECOS 16 , SF-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. We calculated the Spearman’s rank correlation coefficient (r) between MOC-DEXA, ECOS 16, SF12 PCS and MCS scores.

Results: Age, BMD,ECOS 16, SF12 PCS and MCS average (±SD) were: 57.4 years ( ± 10.5); Lumbar Spine T-score -1.69 (± 0.92), Femur T-score -1.39 (± 0.86), ECOS 16  score 2.22 (±  0.81), SF-12 PCS score 35.49 (± 7.34), SF-12 MCS score  45.15  (± 10.32). The Spearman’s rank correlation coefficients (r) and p values are: Lumbar Spine T-score and ECOS-16  r = − 0.17 ; Femur T-score and ECOS-16  r = − 0.10;  Lumbar Spine T-score and PCS  r = − 0.04 ; Lumbar Spine T-score and MCS r = + 0.22 ; Femur T-score and PCS r = + 0.13 ; Femur T-score and MCS r = + 0.15 ; ECOS-16 and PCS r = – 0.47 ; ECOS-16 and MCS r = – 0.19

Conclusion: In our population BMD did not correlate with HRQoL scores using ECOS-16 and SF-12 questionnaires. ECOS-16 scores did not correlate with MCS scores, instead there was an intermediate inverse correlation between the ECOS-16 scores and PCS scores. The combined use of two questionnaires — one specific and one generic — allows us to better capture different aspects of QoL.