Brief Session Description : Neurogenic heterotopic ossification (NHO) is an ectopic bone formation occurring after central nervous system injury. Despite advances in rehabilitation, it remains a frequent, disabling complication causing pain and loss of mobility. Surgery is the only curative option but is complex and high-risk. Emerging therapies now target inflammatory and osteogenic pathways. This workshop offers a translational overview—from mechanisms and early detection to prevention and surgical management—highlighting new therapeutic perspectives bridging research and clinical practice.
Session Objectives:
- Understand the translational mechanisms linking inflammation and NHO formation (from animal to human).
- Identify early clinical and biological markers predictive of NHO development.
- Discuss preventive and therapeutic strategies, including anti-inflammatory and neuro-orthopaedic interventions.
- Review surgical indications and outcomes in NHO patients.
- Highlight emerging directions for preventive treatments and data-driven patient stratification
