800 Section - Long-Term Prospective Assessment of Quality of Life and Physical Function in Malignant Lymphoma Patients Undergoing Chemotherapy

To evaluate longitudinal changes in health state utility values, health-related quality of life, physical function, nutritional status, and fatigue in patients with malignant lymphoma from the start of chemotherapy to 1 year post-chemotherapy.

Design:

This prospective observational study included 21 patients hospitalized for chemotherapy who also received exercise therapy. Assessments were conducted at baseline at admission (BL), post-chemotherapy at discharge, as well as 6 months and 12 months after discharge (6M and12M, respectively). Quality of life was assessed using the SF-6D and SF-36; physical function using handgrip strength, knee extension strength, and the 6-minute walk test; nutritional status using the MNA^®; and fatigue using the BFI. Temporal changes were analyzed using repeated measures ANOVA with Bonferroni correction.

Results:

SF-6D scores improved significantly from 0.571 ± 0.082 at BL to 0.693 ± 0.096 at 12M (p < 0.01). Significant improvements were also found in most SF-36 domains over time, including PF, RP, GH, VT, SF, RE, and MH. Although no significant changes were observed in physical function, it remained stable throughout the study period. MNA^® scores significantly improved at 6M (p < 0.05), and BFI scores significantly improved at both 6M and 12M (p < 0.05 and p < 0.01, respectively).

Conclusion:

Patients with malignant lymphoma undergoing chemotherapy showed significant improvements in SF-6D and SF-36 over 1 year, despite stable physical function. These findings highlight the importance of continued rehabilitation and nutritional support during and after chemotherapy, and offer important evidence to guide long-term care strategies.