Therapeutics
Baljinnyam Avirmed, PhD
Professor, MD
Mongolian National University of Medical Sciences
ulaanbaatar, Ulaanbaatar, Mongolia
Byambanyam Dambiinyam, MD, MD
Rehabilitation doctor
Alpha MEdical Center
Ulaanbaatar, Ulaanbaatar, Mongolia
Galindev Batbold, MD, MD
Rehabilitation doctor
Alpha Medical Rehabilitation Center
Ulaanbaatar, Ulaanbaatar, Mongolia
Sanjidvorov Gerelt-Od, MD, MD
Rehabilitation doctor
Alpha MEdical Center
Ulaanbaatar, Ulaanbaatar, Mongolia
Medial meniscus tear of the knee is a common intra-articular injury that often causes pain, functional impairment, and progressive joint degeneration. Although surgical treatment is sometimes unavoidable, it carries risks such as postoperative instability, recurrence of pain, and accelerated osteoarthritis. In recent years, polydeoxyribonucleotide (PDRN) injection, a biologically active agent promoting tissue regeneration and pain relief, has been increasingly studied as a conservative therapeutic option.
Purpose:To evaluate the therapeutic effectiveness of ultrasound-guided intra-articular PDRN injection in patients with medial meniscus tear.
Design:
Methods: Patients diagnosed with medial meniscus tear were enrolled and divided into two groups. The experimental group received ultrasound-guided intra-articular PDRN injection, while the control group underwent physiotherapy. Clinical outcomes were assessed at 3 weeks using the Visual Analog Scale (VAS) for pain and the Lysholm score for functional recovery.
Results:
Results: Patients treated with PDRN injection demonstrated significantly faster pain reduction compared to the control group (p < 0.05). Functional outcomes, measured by the Lysholm score, were also superior in the PDRN group. Most patients reported reduced pain and stiffness, along with improved range of motion, walking ability, and load-bearing capacity. No adverse events were observed.
Conclusion: Ultrasound-guided intra-articular PDRN injection is a safe and effective conservative treatment option for medial meniscus tear, providing pain relief and functional improvement. However, larger randomized controlled trials with long-term follow-up are needed to confirm its efficacy and safety.
