400 Section - The neurobehavioral characteristics of Left Unilateral Spatial Neglect Following Right-Hemisphere Glioma

Tuesday, May 19, 2026

6:00 PM - 7:30 PM PT

Presenting Author/Autor expositor(s)

RY

Rie Yamawaki, PhD

Chief Occupational Therapist
Rehabilitation Unit, Kyoto University Hospital
Kyoto, Kyoto, Japan

Co-Author/Coautor(s)

YM

Yohei Mineharu, PhD

Associate Professor
Department of Neurosurgery, Kyoto University Graduate School of Medicine: Department of Digital Transformation in Healthcare and Medicine, Kyoto University Graduate School of Medicine
Kyoto, Kyoto, Japan
CU

Chinatsu Umaba, PhD

Occupational Therapist
Rehabilitation Unit, Kyoto University Hospital
Kyoto, Kyoto, Japan
YH

Yoichiro Horikawa, MS

Occupational Therapist
Rehabilitation Unit, Kyoto University Hospital
Kyoto, Kyoto, Japan
KT

Kanade Tanaka, BS

Occupational Therapist
Rehabilitation Unit, Kyoto University Hospital
Kyoto, Kyoto, Japan
KS

Kenta Shigematsu, BS

Occupational Therapist
Rehabilitation Unit, Kyoto University Hospital
Kyoto, Kyoto, Japan
RI

Ryosuke Ikeguchi, PhD

Professor
Rehabilitation Unit, Kyoto University Hospital: Department of Rehabilitation Medicine, Kyoto University Graduate School of Medicine
Kyoto, Kyoto, Japan
YA

Yoshiki Arakawa, PhD

Professor
Department of Neurosurgery, Kyoto University Graduate School of Medicine
Kyoto, Kyoto, Japan

Objectives : Left unilateral spatial neglect (L-USN) is an important factor in rehabilitation because it affects patients’ activities of daily living. Although L-USN is observed in approximately 40% of patients with acute right-hemisphere stroke (Ishiai, 1999), its incidence in brain tumor patients remains unclear. This study aimed to characterize the neurobehavioral characteristics of L-USN in patients with right hemisphere gliomas before surgery.

Design: We retrospectively reviewed 48 right-handed patients with newly diagnosed right-hemisphere glioma who underwent preoperative L-USN assessment at our rehabilitation unit between January 2019 and February 2025. Exclusion criteria included a history of neurological conditions affecting brain function (n = 12) and lack of informed consent (n = 7), leaving 29 patients for analysis. L-USN was evaluated using the 200-mm line bisection test (cut-off: rightward deviation ≥ 10%) and the Star Cancellation Test of the Behavioral Inattention Test (cut-off: detected stars ≤ 51). The study was approved by the Institutional Ethics Committee.

Results: Among the 29 participants, 11 were female, with an average age of 58.5 ± 17.8 years. Tumor types included glioblastoma (n=19), astrocytic tumors (n=4), oligodendroglial tumors (n=5), and unclassified classification (n=1). Seven patients (24.1%) exhibited L-USN, defined as impaired performance on either the line bisection or star cancellation test. All these patients were diagnosed with glioblastoma.

Conclusion: The prevalence of preoperative L-USN in patients with right-hemisphere glioma was lower than previously reported in acute stroke. The absence of L-USN in patients with slow-growing gliomas may reflect neuroplastic reorganization of spatial-attentional networks in response to the tumor's progressive and infiltrative nature.