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Final Program


Final Congress Guide

Therapeutics

1000 Section - Advances in Hydrogel Systems for Bone Regeneration: Trends, Innovations, and Prospects

Wednesday, May 20, 2026
6:00 PM - 7:30 PM PT

    Presenting Author/Autor expositor(s)

  • YH

    Yijing Han, MD

    doctor
    Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, Chinaï¼›Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Chengdu, Sichuan, China (People's Republic)

    • Co-Author/Coautor(s)

  • JL

    Jingying Liu, MD

    doctor
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Chengdu, Sichuan, China (People's Republic)

    • Corresponding Author/Autor a quien dirigir la corr(s)

  • CH

    Chengqi He, MD

    professor
    Sichuan University West China Hospital Rehabilitation Medical Center
    Chengdu, Sichuan, China (People's Republic)

Objectives : This study aims to systematically analyze research trends and hotspots in the field of bone regeneration hydrogels using bibliometric mapping. It seeks to identify key contributors, collaborative networks, and thematic evolution while reviewing cutting-edge biomaterials—such as MSC/EV-loaded hydrogels, dECM-based and SF-based hydrogels, and responsive hydrogels. The work also proposes targeted osteogenic strategies to establish a material-mechanism coupling framework, offering new perspectives for designing advanced bone regeneration materials.

Design: A bibliometric analysis was conducted on literature related to bone regeneration hydrogels from 1990 to 2025. Visualization tools were employed to examine the contributions of countries, institutions, authors, and journals, as well as keyword co-occurrence and citation networks. Combined with a systematic review, the study further evaluated prominent biomaterial strategies, their progress, advantages, and limitations, leading to the formulation of five core design strategies for bone repair.

Results: The analysis revealed exponential growth in annual publications on bone regeneration hydrogels, reflecting increasing research attention. Key hotspots included hydrogels loaded with MSCs/EVs, dECM-based hydrogels, silk fibroin hydrogels, and responsive hydrogels. Moreover, five targeted design strategies were proposed: regulating bone homeostasis, modulating the bone immune microenvironment, promoting vascularized bone regeneration, regulating oxidative stress, and neural regulation. These strategies form a material-mechanism coupling model grounded in biological principles.

Conclusion: This study provides a comprehensive analysis of research trends and emerging strategies in bone regeneration hydrogels. By integrating bibliometric insights with a systematic review, it proposes a novel material-mechanism framework centered on five core design strategies. The work lays a theoretical foundation for future hydrogel-based bone repair materials and offers a valuable reference for advancing research in this field.