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Final Congress Guide

Clinical Sciences/Health Conditions

300 Section - Individualized repetitive transcranial magnetic stimulation concurrent with motor actions promotes post-stroke upper limb recovery: a multi-center, controlled study

Wednesday, May 20, 2026
6:00 PM - 7:30 PM PT

    Presenting Author/Autor expositor(s)

  • YL

    Yang Liu, MS

    Physician
    Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    Shanghai, Shanghai, China (People's Republic)

    • Co-Author/Coautor(s)

  • YW

    Ying WANG, PhD

    Researcher
    Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • JH

    Jieshi HE, PhD

    Researcher
    Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • JL

    Jiamin LI, PhD

    Researcher
    Department of Rehabilitation Medicine, Naval Medical University Changhai Hospital, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • HZ

    Hong ZHANG, MS

    Researcher
    Department of Neurology, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • ZX

    Zhiwei XU, MS

    Researcher
    Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • HZ

    Hui ZHAO, PhD

    Researcher
    Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, CAS Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • QL

    Qiuxu LIU, PhD

    Researcher
    Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • LL

    Lingyu Liu, MD

    chief physician
    Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)，School of Medicine，Tongji University
    shanghai, Shanghai, China (People's Republic)

  • JJ

    Jian Jiang, PhD

    Personalized Transcranial Direct Current Stimulation Model for Treatment of Insomnia Disorder
    Shanghai Quanlan Technology Co., LTD, Shanghai China
    shanghai, Shanghai, China (People's Republic)

  • MP

    Mu-ming POO, PhD

    Director, Senior Investigator
    Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • DL

    Danmei Lan, MD

    Personalized Transcranial Direct Current Stimulation Model for Treatment of Insomnia Disorder
    Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

  • FF

    Fanfu FANG, PhD

    Doctor
    Department of Neurology, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Shanghai, China
    Shanghai, Shanghai, China (People's Republic)

    • Corresponding Author/Autor a quien dirigir la corr(s)

  • JW

    Jixian WANG, MD

    Associate Chief Physician
    Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
    Shanghai, Shanghai, China (People's Republic)

  • QX

    Qing XIE, MD

    Chief Physician
    Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
    Shanghai, Shanghai, China (People's Republic)

Objectives : The efficacy of repetitive transcranial magnetic stimulation (rTMS) in promoting motor recovery after stroke has been variable. We surmise that individualized identification of rTMS target and concurrent application of rTMS with motor actions and may improve the efficac

Design: A prospective multi-center, sham-controlled study in Shanghai, China (NCT06752499, clinicaltrials.gov). Participants had stroke with persistent upper-limb impairment at least 2 weeks before enrollment. Group assignment: I (concurrent rTMS), II (rTMS before motor task), III (sham concurrent rTMS). Individualized targeting determined by TMS induced upper-limb motor evoked potentials (MEPs) or by MRI-guided electric field modeling (if lacking MEPs). The rTMS treatment: 750 pulses/day, 5 days/week for 2 weeks. Primary outcome: change in Fugl-Meyer Upper Extremity (FM-UE) scores (day 0 vs. 105). Safety outcome assayed in all participants.

Results: Sixty participants (20 females) were assigned to Group I (36), II (14), and III (10). Primary outcome: adjusted mean changes (95% CI) in FM-UE (day 105 vs. day 0); Group I (13·27 [10·95 to 15·60]) was significantly higher than Group II (2·48 [-1·55 to 6·52], p < 0·0001) and Group III (3·17 [-1·70 to 8·05], p = 0·012). Group I and II was further subdivided into individualized (I, subset 1; II, subset 3) and non-individualized (I, subset 2; II, subset 4) targeting. Group III was not sub-divided due small sample size. The primary outcome for subset 1 (14·35 [11·82 to 16·87]) was significantly greater than subset 3 (1·76 [−3·06 to 6·58]; p=0·0016) and Group III (3·24 [−1·63 to 8·12]; p = 0·012), whereas subset 2 did not differ from subset 4 (p = 1·00) or Group III (p = 1·00). No severe adverse effect occurred.

Conclusion: Concurrent individualized rTMS improved motor recovery by enhancing long-term potentiation of task-specific circuits that were repetitively activated during motor actions.