1000 Section - Effectiveness of injection Therapy on functioning in patients with De Quervain’s Tenosynovitis: A Systematic Review of Randomized Controlled Trials

Objectives : De Quervain 's disease (DQT) is an inflammation of the tendon sheaths that control the movement of the thumb abductor pollicis longus and extensor pollicis brevis, causing pain and reduction in the functionality of hand and wrist movements. In this context, injection therapy could play a role in reducing the tenosynovitis, however, there is still a lack of consensus on its effectiveness. This systematic review of RCT aims to investigate the effectiveness of   injection therapy of functioning in patients affected by DQT.

Design: PubMed and Scopus were searched from inception to October 2025, to identify RCTs in patients with DQT undergoing infiltrative techniques to improve hand function and reduce pain intensity. The study quality of the RCT reports was independently assessed by 2 reviewers according to the ROB2

Results: Of 206 articles identified, 5 were included in the final synthesis. We analyzed data from 244 patients affected by DQT, reporting significant improvement in function and an overall reduction in pain intensity infiltrative approach rated with Quick DASH score. In particular, the statistical analysis showed that both corticosteroid use and Platelet-Rich Plasma (PRP) treatment could lead to a statistically significant improvement in the Quick DASH score (p < 0.001). Furthermore, 6 months after treatment, a statistically significant difference p < 0.001 was observed with a significant advantage for PRP

Conclusion: This systematic review demonstrated that the application of infiltrative techniques was significantly effective in improving thumb and wrist function. Thus, injections therapy could be considered in the rehabilitation protocol of patients with DQT.