300 Section - A 21-day individual rehabilitation exercise training program changes CRP, cholesterol, aHSG, GDF-15, and IGF-1 levels in patients after hip or knee replacement surgery

Wednesday, May 20, 2026

6:00 PM - 7:30 PM PT

Co-Author/Coautor(s)

AM

Anna Michalik, MD

Dr
Department of Rehabilitation, 3rd Specialist Hospital in Rybnik
Rybnik, Slaskie, Poland
JP

Jakub Poloczek, PhD

Dr
Department of Rehabilitation, 3rd Specialist Hospital in Rybnik,
Rybnik, Slaskie, Poland
KM

Katarzyna Michalczyk, PhD

Dr
Department of Medical Statistics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Sosnowiec, Poland
Zabrze, Slaskie, Poland
EC

Elżbieta Chełmecka, n/a

Professor
Department of Medical Statistics, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Sosnowiec, Poland
Sosnowiec, Slaskie, Poland
MM

Marek Michalski, PhD

Dr
Department of Histology and Cell Pathology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland
Zabrze, Slaskie, Poland
JJ

Jerzy Jochem, MD

Professor
Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Za-brze, Poland;
Zabrze, Slaskie, Poland

Presenting Author/Autor expositor(s)

BS

Bronisława Skrzep-Poloczek, MD

Professor
Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland;
Zabrze, Slaskie, Poland

Corresponding Author/Autor a quien dirigir la corr(s)

DS

Dominika Marta Stygar, n/a

Professor
Department of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, Poland;
Zabrze, Slaskie, Poland

Objectives : Osteoarthritis (OA) is the most prevalent degenerative joint disease and a major cause of disability. Joint arthroplasty remains the primary treatment, yet postoperative rehabilitation plays a key role in recovery and systemic metabolic regulation. The aim of this study was to evaluate the impact of a 21-day individualized postoperative rehabilitation program on functional capacity as well as inflammatory and metabolic markers in patients after hip or knee arthroplasty.

Design:

The study included 42 patients (24 men, 18 women, mean age 61.9 ± 8.0 years), recruited approximately 90 days post-surgery. The program consisted of daily tailored aerobic, strength, and balance exercises, monitored and supervised by specialists. Assessment of rehabilitation effectiveness was performed using the six-minute walk test (6MWT), body weight and BMI measurements, and biochemical analyses of blood parameters including C-reactive protein (CRP), total cholesterol, α2-HS glycoprotein (fetuin-A), growth differentiation factor 15 (GDF-15), and insulin-like growth factor 1 (IGF-1).

Results: Upon completion of the program, a significant improvement was observed in the 6MWT distance (mean increase of 72.2 ± 30.6 m, p< 0.001), reduction in body weight (mean loss of 1.9 ± 1.2 kg, p< 0.001), and BMI (median decrease of 0.7 kg/m², p< 0.001). Additionally, significant decreases were noted in serum levels of CRP, total cholesterol, fetuin-A, GDF-15, and IGF-1 (all p< 0.001). These findings suggest that a short-term, intensive, and individually tailored rehabilitation program not only improves physical performance but also positively modulates systemic inflammation and metabolism in post-arthroplasty patients.

Conclusion:

Systematic rehabilitation exercises following hip or knee arthroplasty should be regarded not only as a physiotherapeutic intervention but also as a health-promoting strategy at the molecular and metabolic levels. Such a rehabilitation program may serve as a crucial non-pharmacological component supporting recovery and the long-term optimization of patient condition after arthroplasty.