1000 Section - Rerenerative Potential of Exosome based Therapy in the Management of Pressure Ulcers:A Clinical Case series

To evaluate the clinical effects of a combined therapeutic protocol using plant-derived exosomes in six patients with chronic pressure ulcers of varying severity (Stages II–III). Chronic pressure ulcers represent a persistent therapeutic challenge, particularly in patients with immobility or neurological impairment. Regenerative modalities such as exosome therapy are emerging as promising adjuncts in chronic wound management. Plant-derived exosomes have recently gained attention for their bioactive and wound-healing properties, though clinical evidence remains limited. As extracellular nanovesicles carrying proteins, lipids and nucleic acids, exosomes play a key role in modulating inflammation, tissue repair and regeneration.

Design:

Six patients with seven chronic pressure ulcers ( >3 months duration) receiving inpatient rehabilitation care in a specialized center underwent surgical debridement to ensure a clean wound bed before treatment initiation. Subsequently, they received regenerative therapy with plant-derived exosomes (ExoCoBio technology) applied via microneedling (1–1.5 mm). Sessions were administered every three days, with a total of five treatments per patient. Ulcers included Stage II (n=2) and Stage III (n=5). Standard wound care continued throughout. Clinical outcomes assessed included wound area reduction, depth improvement, granulation tissue enhancement, exudate level, and rate of complete closure. Safety and tolerability were monitored.

Results:

All six patients demonstrated meaningful clinical improvement following the exosome–microneedling protocol. Wound area reduction was consistent across all cases, accompanied by improved granulation tissue quality, decreased exudate, and overall cleaner wound beds. One Stage II ulcer achieved complete closure after five sessions. No adverse events or treatment-related complications were observed.

Conclusion:

Plant-derived exosome application combined with microneedling appears to be a safe and promising adjunctive strategy for managing chronic pressure ulcers. These preliminary clinical observations support further investigation through controlled trials to validate efficacy and optimize treatment parameters.