Skip to main content
ISPRM 2026 Main banner
Final Program


Final Congress Guide

Biomedical Sciences

100 Section - Roles of IL-11 in the regulation of bone metabolism

Tuesday, May 19, 2026
6:00 PM - 7:30 PM PT

    Presenting Author/Autor expositor(s)

  • YH

    Yijing Han, MD

    doctor
    Institute for Disaster Management and Reconstruction, Sichuan University-The Hong Kong Polytechnic University, Chengdu, China；Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Chengdu, Sichuan, China (People's Republic)

    • Co-Author/Coautor(s)

  • JL

    Jingying Liu, MD

    doctor
    Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Chengdu, Sichuan, China (People's Republic)

    • Corresponding Author/Autor a quien dirigir la corr(s)

  • CH

    Chengqi He, MD

    professor
    Sichuan University West China Hospital Rehabilitation Medical Center
    Chengdu, Sichuan, China (People's Republic)

Objectives :

Bone metabolism is the basis for maintaining the normal physiological state of bone, and imbalance of bone metabolism can lead to a series of metabolic bone diseases. As a member of the IL-6 family, IL-11 acts primarily through the classical signaling pathway IL-11/Receptors, IL-11 (IL-11R)/Glycoprotein 130 (gp130). The regulatory role of IL-11 in bone metabolism has been found earlier but mainly focuses on the effects on osteogenesis and osteoclasis. In recent years, more studies have focused on IL-11’s roles and related mechanisms in different bone metabolism activities. IL-11 regulates osteoblasts, osteoclasts, bone marrow (BM) stromal cells, adipose tissue-derived mesenchymal stem cells, and chondrocytes. It’s involved in bone homeostasis, including osteogenesis, osteolysis, BM hematopoiesis, BM adipogenesis, and bone metastasis.

Design:


  • From January 1992 to January 2023, use the keywords (Interleukin-11 OR Receptors, Interleukin-11), (Bone) AND (Interleukin-11 OR Receptors, Interleukin-11) , (Bone Marrow) AND (Interleukin-11 OR Receptors,Interleukin-11) , (Bone OR Bone Marrow) AND (Interleukin-11 OR Receptors,Interleukin-11) AND (Adipocytes OR Fat). The databases of Medline, PubMed, Cochrane, Web of Science, Embase and Google Scholar were searched.



Results: This article will briefly summarize the role of IL-11 in inflammatory diseases, detail the regulatory role and related mechanisms of IL-11 in bone metabolism, and provide new ideas for the studies and treatment of metabolic bone diseases.

Conclusion:

Understanding the regulatory role of IL-11 in bone metabolism and its interplay with other pathways, such as the Wnt/β-catenin signaling pathway, is crucial for developing new therapeutic strategies for bone diseases. Future research should focus on elucidating the detailed mechanisms by which IL-11 and LIPUS interact to modulate bone metabolism and exploring their potential clinical applications.