1000 Section - Comparison between Topical Platelet Rich Plasma and Normal Saline Dressing, in conjunction with Total Contact Casting in Treatment of Diabetic Foot Ulcer– a Randomized Control Trial

Objectives : To compare the efficacy and to assess the decrease in mean healing time and PUSH score (Pressure Ulcer Scale for Healing)between topical platelet rich plasma (PRP) and normal saline (NS) dressing when used in conjunction
with total contact casting (TCC) for the treatment of diabetic foot ulcer (DFU).

Design: This RCT done in Department of PMR  on patients meeting inclusion criteria.The Institutional Ethical Committee ofAll India Institute of Medical Science Patna (AIIMS PATNA )certified it.

Study Population(N): The study population was estimated using statistical formulae, and 36
patients were considered in each group based .
The patients were randomized into two groups. The patients in the first group were given PRP therapy along with
TCC, whereas the patients in the second group were given NS dressing along with TCC.

Results: The study, a prospective RCT , showed that the PRP group had a significantly higher complete healing rate at 90 days (77.78%) compared to the NS group (44.44%). The mean time to heal was also significantly shorter in the PRP group (11.17 weeks vs. 13.78 weeks). Furthermore, PRP led to a greater reduction in wound size and a greater improvement in the PUSH score at multiple follow-up points.
The groups were well-matched for key characteristics, strengthening the conclusion that PRP therapy is superior for accelerating wound healing in diabetic foot ulcers.

Conclusion: In this study, we demonstrated that both PRP and NS dressing are beneficial and effective in the
treatment of Diabetic foot ulcer when used in conjunction with TCC in improving healing rate. Even
though both treatments are beneficial, the results of this study indicate that PRP therapy is statistically
superior to NS dressing. These results were consistent with those of previous research, but we believe
that additional evaluations may be required with a long term follow up period.