Clinical Sciences/Health Conditions
ZEYU wang, n/a
Physician
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
chen zhi, MD
Master’s graduate
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
jin yan, MD
Master’s graduate
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
siqi yang, MD
Physician
Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium
Brussels, Brussels Hoofdstedelijk Gewest, Belgium
Yang Liu, MS
Physician
Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai, Shanghai, China (People's Republic)
yongjun qiao, MD
Therapist
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
siyu yin, MD
Therapist
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
huijia zhou, n/a
Master’s graduate
College of Biological Sciences, University of California
Davis, California, United States
Jixian WANG, MD
Associate Chief Physician
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai, China (People's Republic)
huijuan pan, MD
Chief Physician
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
qing xie, PhD
Chief Physician
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
shanghai, Shanghai, China (People's Republic)
Chuanxin Niu, PhD
Associate researcher
Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University
shanghai, Shanghai, China (People's Republic)
Stroke impairs coordinated upper-extremity movements vital for daily tasks. Therapeutic exercises also demand such large-extent movements, which have shown improved benefits with added mechanical loading. Previous studies have demonstrated proportional responses of motor cortices to load inertia in healthy individuals, but such effects unlikely preserve in patients with stroke due to impaired cortical control. Here we aim to answer whether the proportional increase in hemodynamic responses to mechanical loads would preserve in patients with stroke. We hypothesize that some, if not all, motor-related regions may still show load-related increases in stroke.
Design:
We measured the hemodynamic signals of 10 stroke patients performing lifting 0 kg, 1 kg and 2 kg of load, and 10 healthy subjects performing lifting 0 pounds, 3 pounds, and 15 pounds of load. Cortical activation was calculated from 4 repetition of tasks arranged into 12 randomized blocks. By comparing the cortical activation patterns of patients with stroke and healthy subjects, we explored the correlation between mechanical load and cortical activation to understand how the cortical activation pattern changes with load inertia.
Results: In patients with stroke, when lifting with the affected arm, significant linear correlation was detected in the ipsilesional PPC (Ch6, p < 0.001, conditional.; Ch7, p< 0.05). Other than PPC, no significant correlations were found in both contralesional and ipsilesional sides. In healthy subjects, when lifting with the arm, significant linear correlations were observed in M1, SMA, PMC, part of PPC in the hemisphere contralateral to the moving limb.
Conclusions:
In patients with stroke, the activation increased significantly with increasing load in the posterior parietal cortex (PPC) but no other motor-related cortices (M1, SMA, PMC). In healthy individuals, the proportional responses to increasing load have been replicated in all ROIs in motor-related cortices.
